Neuroprotective effect of asymmetric dimethylarginine against 1‐methyl‐4‐phenylpyridinium ion‐induced damage in PC12 cells
Identifieur interne : 000630 ( Main/Exploration ); précédent : 000629; suivant : 000631Neuroprotective effect of asymmetric dimethylarginine against 1‐methyl‐4‐phenylpyridinium ion‐induced damage in PC12 cells
Auteurs : Xiao-Qing Tang [République populaire de Chine] ; Yu-Juan Li ; Jing Zhao ; Xing-Tian Shen ; Chun-Tao Yang ; Li-Li Fan ; Bi Hu ; Yuan-Jian Li ; Duan-Fan Liao [République populaire de Chine]Source :
- Clinical and Experimental Pharmacology and Physiology [ 0305-1870 ] ; 2010-05.
English descriptors
- KwdEn :
Abstract
1. Asymmetric dimethylarginine (ADMA) is a well‐known endogenous nitric oxide synthase (NOS) inhibitor. Although it has been shown to be a novel risk marker in cardiovascular medicine and chronic kidney disease, we speculated that in some states associated with excess of nitric oxide (NO), such as 1‐methyl‐4‐phenylpyridinium ion (MPP+)‐induced neuronal injury, ADMA might be protective by limiting the toxic effect of high concentrations of NO. 2. The aim of the present study is to explore the protection of ADMA against MPP+‐induced apoptosis and the molecular mechanisms underlying in PC12 cells. 3. We found that exogenous application of ADMA obviously protected PC12 cells against MPP+‐induced cytotoxicity and apoptosis not only by reducing the loss of mitochondrial membrane potential, but also by attenuating an increase in intracellular reactive oxygen species. Moreover, ADMA attenuated MPP+‐induced excessive activation of nitric oxide synthase and overproduction of NO. 4. The results of the present study suggest that the protection caused by ADMA is related to preserving mitochondrial membrane potential and attenuating the MPP+‐induced intracellular reactive oxygen species generation through inhibiting nitric oxide synthase activity and limiting NO generation.
Url:
DOI: 10.1111/j.1440-1681.2010.05344.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroprotective effect of asymmetric dimethylarginine against 1‐methyl‐4‐phenylpyridinium ion‐induced damage in PC12 cells</title><author><name sortKey="Tang, Xiao Ing" sort="Tang, Xiao Ing" uniqKey="Tang X" first="Xiao-Qing" last="Tang">Xiao-Qing Tang</name></author><author><name sortKey="Li, Yu Uan" sort="Li, Yu Uan" uniqKey="Li Y" first="Yu-Juan" last="Li">Yu-Juan Li</name></author><author><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></author><author><name sortKey="Shen, Xing Ian" sort="Shen, Xing Ian" uniqKey="Shen X" first="Xing-Tian" last="Shen">Xing-Tian Shen</name></author><author><name sortKey="Yang, Chun Ao" sort="Yang, Chun Ao" uniqKey="Yang C" first="Chun-Tao" last="Yang">Chun-Tao Yang</name></author><author><name sortKey="Fan, Li I" sort="Fan, Li I" uniqKey="Fan L" first="Li-Li" last="Fan">Li-Li Fan</name></author><author><name sortKey="Hu, Bi" sort="Hu, Bi" uniqKey="Hu B" first="Bi" last="Hu">Bi Hu</name></author><author><name sortKey="Li, Yuan Ian" sort="Li, Yuan Ian" uniqKey="Li Y" first="Yuan-Jian" last="Li">Yuan-Jian Li</name></author><author><name sortKey="Liao, Duan An" sort="Liao, Duan An" uniqKey="Liao D" first="Duan-Fan" last="Liao">Duan-Fan Liao</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:42BF4CC5CF207530C0E9085FC68A8575651F3372</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1440-1681.2010.05344.x</idno><idno type="url">https://api.istex.fr/document/42BF4CC5CF207530C0E9085FC68A8575651F3372/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002B11</idno><idno type="wicri:Area/Main/Curation">002747</idno><idno type="wicri:Area/Main/Exploration">000630</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neuroprotective effect of asymmetric dimethylarginine against 1‐methyl‐4‐phenylpyridinium ion‐induced damage in PC12 cells</title><author><name sortKey="Tang, Xiao Ing" sort="Tang, Xiao Ing" uniqKey="Tang X" first="Xiao-Qing" last="Tang">Xiao-Qing Tang</name><affiliation><wicri:noCountry code="subField">Hengyang</wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Pharmacy and Pharmacology, Life Science Research Center, University of South China, Hengyang</wicri:regionArea><wicri:noRegion>Hengyang</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yu Uan" sort="Li, Yu Uan" uniqKey="Li Y" first="Yu-Juan" last="Li">Yu-Juan Li</name><affiliation><wicri:noCountry code="subField">Hengyang</wicri:noCountry></affiliation></author><author><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name><affiliation><wicri:noCountry code="subField">Hengyang</wicri:noCountry></affiliation></author><author><name sortKey="Shen, Xing Ian" sort="Shen, Xing Ian" uniqKey="Shen X" first="Xing-Tian" last="Shen">Xing-Tian Shen</name><affiliation><wicri:noCountry code="subField">Hengyang</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Chun Ao" sort="Yang, Chun Ao" uniqKey="Yang C" first="Chun-Tao" last="Yang">Chun-Tao Yang</name><affiliation><wicri:noCountry code="subField">Hengyang</wicri:noCountry></affiliation></author><author><name sortKey="Fan, Li I" sort="Fan, Li I" uniqKey="Fan L" first="Li-Li" last="Fan">Li-Li Fan</name><affiliation><wicri:noCountry code="subField">Hengyang</wicri:noCountry></affiliation></author><author><name sortKey="Hu, Bi" sort="Hu, Bi" uniqKey="Hu B" first="Bi" last="Hu">Bi Hu</name><affiliation><wicri:noCountry code="subField">Hengyang</wicri:noCountry></affiliation></author><author><name sortKey="Li, Yuan Ian" sort="Li, Yuan Ian" uniqKey="Li Y" first="Yuan-Jian" last="Li">Yuan-Jian Li</name><affiliation><wicri:noCountry code="subField">Changsha</wicri:noCountry></affiliation></author><author><name sortKey="Liao, Duan An" sort="Liao, Duan An" uniqKey="Liao D" first="Duan-Fan" last="Liao">Duan-Fan Liao</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Pharmacy and Pharmacology, Life Science Research Center, University of South China, Hengyang</wicri:regionArea><wicri:noRegion>Hengyang</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical and Experimental Pharmacology and Physiology</title><idno type="ISSN">0305-1870</idno><idno type="eISSN">1440-1681</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-05">2010-05</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">5‐6</biblScope><biblScope unit="page" from="530">530</biblScope><biblScope unit="page" to="535">535</biblScope></imprint><idno type="ISSN">0305-1870</idno></series><idno type="istex">42BF4CC5CF207530C0E9085FC68A8575651F3372</idno><idno type="DOI">10.1111/j.1440-1681.2010.05344.x</idno><idno type="ArticleID">CEP5344</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1870</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1‐methyl‐4‐phenylpyridinium ion</term><term>Parkinson’s disease</term><term>asymmetric dimethylarginine</term><term>neuroprotection</term><term>nitric oxide</term><term>nitric oxide synthase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. Asymmetric dimethylarginine (ADMA) is a well‐known endogenous nitric oxide synthase (NOS) inhibitor. Although it has been shown to be a novel risk marker in cardiovascular medicine and chronic kidney disease, we speculated that in some states associated with excess of nitric oxide (NO), such as 1‐methyl‐4‐phenylpyridinium ion (MPP+)‐induced neuronal injury, ADMA might be protective by limiting the toxic effect of high concentrations of NO. 2. The aim of the present study is to explore the protection of ADMA against MPP+‐induced apoptosis and the molecular mechanisms underlying in PC12 cells. 3. We found that exogenous application of ADMA obviously protected PC12 cells against MPP+‐induced cytotoxicity and apoptosis not only by reducing the loss of mitochondrial membrane potential, but also by attenuating an increase in intracellular reactive oxygen species. Moreover, ADMA attenuated MPP+‐induced excessive activation of nitric oxide synthase and overproduction of NO. 4. The results of the present study suggest that the protection caused by ADMA is related to preserving mitochondrial membrane potential and attenuating the MPP+‐induced intracellular reactive oxygen species generation through inhibiting nitric oxide synthase activity and limiting NO generation.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Fan, Li I" sort="Fan, Li I" uniqKey="Fan L" first="Li-Li" last="Fan">Li-Li Fan</name><name sortKey="Hu, Bi" sort="Hu, Bi" uniqKey="Hu B" first="Bi" last="Hu">Bi Hu</name><name sortKey="Li, Yu Uan" sort="Li, Yu Uan" uniqKey="Li Y" first="Yu-Juan" last="Li">Yu-Juan Li</name><name sortKey="Li, Yuan Ian" sort="Li, Yuan Ian" uniqKey="Li Y" first="Yuan-Jian" last="Li">Yuan-Jian Li</name><name sortKey="Shen, Xing Ian" sort="Shen, Xing Ian" uniqKey="Shen X" first="Xing-Tian" last="Shen">Xing-Tian Shen</name><name sortKey="Yang, Chun Ao" sort="Yang, Chun Ao" uniqKey="Yang C" first="Chun-Tao" last="Yang">Chun-Tao Yang</name><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Tang, Xiao Ing" sort="Tang, Xiao Ing" uniqKey="Tang X" first="Xiao-Qing" last="Tang">Xiao-Qing Tang</name></noRegion><name sortKey="Liao, Duan An" sort="Liao, Duan An" uniqKey="Liao D" first="Duan-Fan" last="Liao">Duan-Fan Liao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000630 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000630 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:42BF4CC5CF207530C0E9085FC68A8575651F3372
|texte= Neuroprotective effect of asymmetric dimethylarginine against 1‐methyl‐4‐phenylpyridinium ion‐induced damage in PC12 cells
}}
| This area was generated with Dilib version V0.6.23. |  |